A hormone-free pill, called YCT-529, that temporarily stops sperm production by blocking a vitamin A metabolite has just concluded its first safety trial in humans, getting a step closer to increasing male contraceptive options
Could it be the first one to pass this test phase?
To study the safety of YCT-529 in humans, we conducted a Phase 1a clinical trial where 16 healthy men received either placebo or escalating single doses of YCT-529 to assess its safety and tolerability. YCT-529 was well tolerated, and no adverse effects were noted. The positive results from this first clinical trial laid the groundwork for a second trial, where men receive YCT-529 for 28 days and 90 days, to study safety and changes in sperm parameters.
Could it be the first one to pass this test phase?
It looks like the hormonal NES/T male contraceptive gel passed safety a while back and started phase 2 trials in 2018. It’s already gearing up for phase 3 trials with investors ready to fund this final phase:
https://www.einpresswire.com/article/835140008/contraline-exercises-license-option-for-nes-t-the-first-male-contraceptive-to-reach-late-stage-development
But a hormone-free option is more appealing. I hope YCT-529 makes it to the finish line.